When Los Angeles' newly elected Sheriff dies, Bill Hollister is suddenly propelled into the role leading one of the largest police forces in the world. Only interested in justice, Bill commands a county-wide crew of LA's finest, including Deputy Cade Ward, Deputy Brianna Bishop and Deputy Joseph Harris. The dangers of the job often lead to the LA County General Hospital, where Bill frequently has run-ins with Dr. Paula Reyes the hospital's chief trauma surgeon and his wife.