When a bomb explodes outside the hospital, TC (Eoin Macken), Topher (Ken Leung) and Drew (Brendan Fehr) are forced to make the tough decision to stay and treat the injured or evacuate and begin transfers to nearby hospitals. Everything changes when TC suddenly realizes he may know the person responsible for the explosion. While the team works feverishly to tend to the wounded, the nurses go on strike just when the hospital needs them the most. Meanwhile, throughout the intense night shift, Shannon (Tanaya Beatty) and Paul (Robert Bailey, Jr.) attempt to confront each other about something personal.